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KMID : 0620920110430110622
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Experimental & Molecular Medicine
2011 Volume.43 No. 11 p.622 ~ p.629
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Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma
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Yang Hee-Seok
Shin Jae-Hoon
Bhang Suk-Ho
Shin Jung-Youn
Park Joo-Yeon
Im Gun-Il
Kim Chang-Sung
Kim Byung-Soo
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Abstract
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Platelet-rich plasma (PRP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we hypothesize that treatment of skin wound with a mixture of PRP and HCF exerts sustained release of several growth factors contained in PRP and promotes skin wound healing. The release of fibroblast growth factor 2, platelet-derived growth factor-BB, and vascular endothelial growth factor contained in PRP from HCF was sustained for a longer period than those from PRP, calcium-activated PRP (C-PRP), or a mixture of fibrin and PRP (F-PRP). Treatment of full-thickness skin wounds in mice with HCF-PRP resulted in much faster wound closure as well as dermal and epidermal regeneration at day 12 compared to treatment with either C-PRP or F-PRP. Enhanced skin regeneration observed in HCF-PRP group may have been at least partially due to enhanced angiogenesis in the wound beds. Therefore, this method could be useful for skin wound treatment.
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KEYWORD
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angiogenesis inducing agents, endothelial growth factors, fibrin, fibroblast growth factor 2, heparin, neovascularization, physiologic, platelet-derived growth factor, platelet-rich plasma, wound healing
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